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SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)

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Generally, when formulations are based on FDA-approved bulk substances or compliant ingredient components, they can fall within regulatory guidelines when prescribed and dispensed appropriately. Dr

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Injections are one option a provider may recommend when a deficiency is confirmed, especially when absorption is a concern